Goethe University Frankfurt
Goethe University Frankfurt is known for its strong emphasis on research across diverse fields, including social sciences, humanities, and natural sciences. The university fosters a dynamic academic environment with a commitment to academic freedom and a focus on societal relevance and innovation.
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Christine Ecker
Christine Ecker is a professor at Goethe University Frankfurt, specializing in clinical neuroscience and psychiatry.
Christine Margarete Freitag
C04: The sex-specific role of genes, early adversity, peers, community violence, and puberty related endocrinological changes in adolescent pathological aggression
Q01: Recruitment and biotyping transdiagnostic risk mechanisms for aggressive behaviors in mental disorders across the life span
Principal investigator
Goethe University Frankfurt
Professor Christine M Freitag focuses on Translational research in Neurodevelopmental, Anxiety and Disruptive Behavior Disorders in children and youth.
Sabine Herpertz
A02: Context effects on threat processing in dependence of testosterone levels
C06: Brain mechanisms differentiating aggressive vs. non-aggressive psychopathology as sequelae of early life maltreatment
Q01: Recruitment and biotyping transdiagnostic risk mechanisms for aggressive behaviors in mental disorders across the life span
Principal investigator
Deputy Spokesperson
Goethe University Frankfurt
Prof Dr Sabine C.
Andreas Reif
A07: The intestinal microbiota as a regulator of aggressive and impulsive behavior
B01: Neurobehavioral effects of repetitive prefrontal transcranial direct current stimulation (tDCS) on pathological aggression
Q01: Recruitment and biotyping transdiagnostic risk mechanisms for aggressive behaviors in mental disorders across the life span
Principal investigator
Deputy Spokesperson
Goethe University Frankfurt
David Slattery
A07: The intestinal microbiota as a regulator of aggressive and impulsive behavior
A08: The metabolic lung-brain axis in aggressive behavior in patients with AMD
C01: Gene-environment interactions and the role of impulsivity in responding to acute threats: early life stress and escalated aggression in recombinant inbred mouse strains
Q03: Integrated Research Training Group (RTG)
Principal investigator
Goethe University Frankfurt
Professor David Slattery is interested in understanding of the neurobiology and treatment of stress-related disorders; with an emphasis on mood and anxiety disorders.
A07: The intestinal microbiota as a regulator of aggressive and impulsive behavior
This translational project investigates sex-dependent behavioral effects of faecal microbiota transplantation to microbiome-depleted mice from AMD patients (selected based on their aggressive and impulsive traits from Q01), as well as healthy controls.
A08: The metabolic lung-brain axis in aggressive behavior in patients with AMD
Beta-hydroxy-butyrate (BHB), a ketone body, is negatively associated with aggressive behavior.
B01: Neurobehavioral effects of repetitive prefrontal transcranial direct current stimulation (tDCS) on pathological aggression
TDCS will be used as an interventional tool to decrease aggression.
C01: Gene-environment interactions and the role of impulsivity in responding to acute threats: early life stress and escalated aggression in recombinant inbred mouse strains
Sex-dependent effects and gene-environment interactions will be investigated by applying escalating aggression paradigms.
C04: The sex-specific role of genes, early adversity, peers, community violence, and puberty related endocrinological changes in adolescent pathological aggression
Address sex-specific NVS (reactive aggression) and CS (different dimensions of psychopathy, proactive aggression) associated risk factors, and risk factor-based biosignatures.
C05: The neuroanatomical underpinnings of clinical aggression and their relationship with the negative valence and cognitive control systems
Link questionnaire measures of aggression to specific neural substrates using structural MRI.
C07: Identifying mediators of threat-aggression and experimental manipulation by tDCS
Test the interaction of the CS and frustrative non-reward as part of the NVS.
Q01: Recruitment and biotyping transdiagnostic risk mechanisms for aggressive behaviors in mental disorders across the life span
Tobias Banaschewski
Thomas Frodl
Sabine Herpertz
Andreas Reif
Christine Margarete Freitag
Ute Habel
Kerstin Konrad
Service project
RWTH Aachen
Central Institute of Mental Health
Heidelberg University
Goethe University Frankfurt
Biological Psychiatry
Clinical Psychiatry, Psychotherapy, Child and Adolescent Psychiatry
The central recruitment platform for collecting and curating a longitudinal dataset for studying individual aggression dynamics related to the neural, cognitive-emotional, neurobiological, psychopathological and environmental factors in patient groups.
Q03: Integrated Research Training Group (RTG)
Bundle all training and mentoring activities in a research training group (RTG) for the young researchers participating in this collaborative research center.